NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells

NODAL/TGFβ signalling mediates the self-sustained stemness induced by PIK3CAH1047R homozygosity in pluripotent stem cells

Activating PIK3CA mutations are known 'drivers' of human cancer and developmental overgrowth syndromes. We recently demonstrated that the 'hotspot' PIK3CAH1047R variant exerts unexpected allele dose-dependent effects on stemness in human pluripotent stem cells (hPSCs). In this st...

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Main Authors: Ralitsa R. Madsen (Author), James Longden (Author), Rachel G. Knox (Author), Xavier Robin (Author), Franziska Völlmy (Author), Kenneth G. Macleod (Author), Larissa S. Moniz (Author), Neil O. Carragher (Author), Rune Linding (Author), Bart Vanhaesebroeck (Author), Robert K. Semple (Author)
Format: Book
Published: The Company of Biologists, 2021-03-01T00:00:00Z.
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