Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control

• Main Authors: Qiang Liu (Author), Pankaj Garg (Author), Burcu Hasdemir (Author), Linya Wang (Author), Emily Tuscano (Author), Emily Sever (Author), Erica Keane (Author), Ana G Lujan Hernandez (Author), Tom Z. Yuan (Author), Eric Kwan (Author), Joyce Lai (Author), Greg Szot (Author), Sreenivasan Paruthiyil (Author), Fumiko Axelrod (Author), Aaron K. Sato (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

G protein-coupled receptors (GPCRs) are a group of seven-transmembrane receptor proteins that have proven to be successful drug targets. Antibodies are becoming an increasingly promising modality to target these receptors due to their unique properties, such as exquisite specificity, long half-life,...