Transcriptional signature in microglia isolated from an Alzheimer's disease mouse model treated with scanning ultrasound

• Main Authors: Gerhard Leinenga (Author), Liviu‐Gabriel Bodea (Author), Jan Schröder (Author), Giuzhi Sun (Author), Yichen Zhou (Author), Jae Song (Author), Alexandra Grubman (Author), Jose M. Polo (Author), Jürgen Götz (Author)
• Format: Book
• Published: Wiley, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Transcranial scanning ultrasound combined with intravenously injected microbubbles (SUS+MB) has been shown to transiently open the blood-brain barrier and reduce the amyloid‐β (Aβ) pathology in the APP23 mouse model of Alzheimer's disease (AD). This has been accomplished through the ac...