An Antibacterial Peptide with High Resistance to Trypsin Obtained by Substituting <span style="font-variant: small-caps">d</span>-Amino Acids for Trypsin Cleavage Sites

• Main Authors: Xiaoou Zhao (Author), Mengna Zhang (Author), Inam Muhammad (Author), Qi Cui (Author), Haipeng Zhang (Author), Yu Jia (Author), Qijun Xu (Author), Lingcong Kong (Author), Hongxia Ma (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The poor stability of antibacterial peptide to protease limits its clinical application. Among these limitations, trypsin mainly exists in digestive tract, which is an insurmountable obstacle to orally delivered peptides. OM19R is a random curly polyproline cationic antimicrobial peptide, which has...