A Hybrid Approach Combining Shape-Based and Docking Methods to Identify Novel Potential P2X7 Antagonists from Natural Product Databases

• Main Authors: Natiele Carla da Silva Ferreira (Author), Lucas Gasparello Viviani (Author), Lauro Miranda Lima (Author), Antonia Tavares do Amaral (Author), João Victor Paiva Romano (Author), Anderson Lage Fortunato (Author), Rafael Ferreira Soares (Author), Anael Viana Pinto Alberto (Author), Jose Aguiar Coelho Neto (Author), Luiz Anastacio Alves (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

P2X7 is an ATP-activated purinergic receptor implicated in pro-inflammatory responses. It is associated with the development of several diseases, including inflammatory and neurodegenerative conditions. Although several P2X7 receptor antagonists have recently been reported in the literature, none of...