Impairment of Mitochondrial Biogenesis and Dynamics Involved in Isoniazid-Induced Apoptosis of HepG2 Cells Was Alleviated by p38 MAPK Pathway

• Hoofdauteurs: Tianguang Zhang (Auteur), Takashi Ikejima (Auteur), Lizhong Li (Auteur), Ruiqin Wu (Auteur), Xiaoyan Yuan (Auteur), Jun Zhao (Auteur), Yimei Wang (Auteur), Shuangqing Peng (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2017-10-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Isoniazid (INH), a widely used first-line antitubercular drug, has been noted to be associated with hepatotoxicity. In spite of extensive researches over many decades, the mechanism of INH-induced hepatotoxicity still remains poorly understood. Recently, mitochondrial toxicity has been emerging as a...