Sex and Circadian Timing Modulate Oxaliplatin Hematological and Hematopoietic Toxicities

• Главные авторы: Sandrine Dulong (Автор), Lucas Eduardo Botelho de Souza (Автор), Jean Machowiak (Автор), Benoit Peuteman (Автор), Gaelle Duvallet (Автор), Déborah Boyenval (Автор), Elise Roth (Автор), Afag Asgarova (Автор), Yunhua Chang (Автор), Xiao-Mei Li (Автор), Adlen Foudi (Автор), Annabelle Ballesta (Автор)
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• Опубликовано: MDPI AG, 2022-11-01T00:00:00Z.
• Предметы: article
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Oxaliplatin was nearly twice as hematotoxic, with optimal circadian timing differing by 6 h, in women as compared to men with colorectal cancers. Hence, we investigated sex- and timing-related determinants of oxaliplatin hematopoietic toxicities in mice. Body-weight loss (BWL), blood cell counts, bo...