Sex and Circadian Timing Modulate Oxaliplatin Hematological and Hematopoietic Toxicities

• Main Authors: Sandrine Dulong (Author), Lucas Eduardo Botelho de Souza (Author), Jean Machowiak (Author), Benoit Peuteman (Author), Gaelle Duvallet (Author), Déborah Boyenval (Author), Elise Roth (Author), Afag Asgarova (Author), Yunhua Chang (Author), Xiao-Mei Li (Author), Adlen Foudi (Author), Annabelle Ballesta (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxaliplatin was nearly twice as hematotoxic, with optimal circadian timing differing by 6 h, in women as compared to men with colorectal cancers. Hence, we investigated sex- and timing-related determinants of oxaliplatin hematopoietic toxicities in mice. Body-weight loss (BWL), blood cell counts, bo...