Is there an epigenetic component underlying the resistance of triple-negative breast cancers to PARP inhibitors?

• Glavni autori: Amanda eLovato (Autor), Lawrence ePanasci (Autor), Michael eWitcher (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2012-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Poly(ADP-ribose)polymerase (Parp) is an enzyme responsible for catalyzing post-translational modifications through the addition of poly(ADP-ribose) chains (known as PARylation). Modification by PARylation modulates numerous cellular processes including transcription, chromatin remodeling, apoptosis...