Sources of inter-individual variability leading to significant changes in anti-PD-1 and anti-PD-L1 efficacy identified in mouse tumor models using a QSP framework

• Principais autores: Jessica C. Leete (Autor), Michael G. Zager (Autor), Cynthia J. Musante (Autor), Blerta Shtylla (Autor), Wenlian Qiao (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

While anti-PD-1 and anti-PD-L1 [anti-PD-(L)1] monotherapies are effective treatments for many types of cancer, high variability in patient responses is observed in clinical trials. Understanding the sources of response variability can help prospectively identify potential responsive patient populati...