Fliposomes: pH-Sensitive Liposomes Containing a trans-2-morpholinocyclohexanol-Based Lipid That Performs a Conformational Flip and Triggers an Instant Cargo Release in Acidic Medium

• Main Authors: Barbora Brazdova (Author), Andreas H. Franz (Author), Vyacheslav V. Samoshin (Author), Xin Guo (Author), Xin Liu (Author), Nataliya M. Samoshina (Author)
• Format: Book
• Published: MDPI AG, 2011-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic conformational flip upon protonation that disrupts the liposome membrane and causes rapid release of cargo specifically in areas of increased acidity. pH-sensitive liposomes containing the amphiphile (1) w...