Fliposomes: pH-Sensitive Liposomes Containing a trans-2-morpholinocyclohexanol-Based Lipid That Performs a Conformational Flip and Triggers an Instant Cargo Release in Acidic Medium

• Auteurs principaux: Barbora Brazdova (Auteur), Andreas H. Franz (Auteur), Vyacheslav V. Samoshin (Auteur), Xin Guo (Auteur), Xin Liu (Auteur), Nataliya M. Samoshina (Auteur)
• Format: Livre
• Publié: MDPI AG, 2011-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Incorporation of a pH-sensitive conformational switch into a lipid structure enables a drastic conformational flip upon protonation that disrupts the liposome membrane and causes rapid release of cargo specifically in areas of increased acidity. pH-sensitive liposomes containing the amphiphile (1) w...