New Compounds with Bioisosteric Replacement of Classic Choline Kinase Inhibitors Show Potent Antiplasmodial Activity

• Main Authors: Francisco José Aguilar-Troyano (Author), Archimede Torretta (Author), Gianluca Rubbini (Author), Alberto Fasiolo (Author), Pilar María Luque-Navarro (Author), María Paz Carrasco-Jimenez (Author), Guiomar Pérez-Moreno (Author), Cristina Bosch-Navarrete (Author), Dolores González-Pacanowska (Author), Emilio Parisini (Author), Luisa Carlota Lopez-Cara (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the fight against Malaria, new strategies need to be developed to avoid resistance of the parasite to pharmaceutics and other prevention barriers. Recently, a Host Directed Therapy approach based on the suppression of the starting materials uptake from the host by the parasite has provided excell...