Biased computation of probability of target attainment for antimicrobial drugs

• Main Authors: Pierre‐Louis Toutain (Author), Peggy Gandia (Author), Ludovic Pelligand (Author), Aude A. Ferran (Author), Peter Lees (Author), Alain Bousquet‐Mélou (Author), Didier Concordet (Author)
• Format: Book
• Published: Wiley, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The medical literature is replete with articles in which there is confusion between "free concentration" and "unbound fraction" (fu), which is the ratio of free to total plasma concentration. The lack of clarity in distinguishing between these two terms has led to biased...