3D Spheroids of Human Primary Urine-Derived Stem Cells in the Assessment of Drug-Induced Mitochondrial Toxicity

• Principais autores: Huifen Ding (Autor), Kalyani Jambunathan (Autor), Guochun Jiang (Autor), David M. Margolis (Autor), Iris Leng (Autor), Michael Ihnat (Autor), Jian-Xing Ma (Autor), Jon Mirsalis (Autor), Yuanyuan Zhang (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2022-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Mitochondrial toxicity (Mito-Tox) risk has increased due to the administration of several classes of drugs, particularly some life-long antiretroviral drugs for HIV⁺ individuals. However, no suitable in vitro assays are available to test long-term Mito-Tox (≥4 weeks). The goal...