Conservation analysis and pathogenicity prediction of mutant genes of ectodysplasin a

• Main Authors: Fangqi He (Author), Hongfeng Wang (Author), Xiaoyu Zhang (Author), Qingping Gao (Author), Feng Guo (Author), Chang Chen (Author)
• Format: Book
• Published: BMC, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Hypohidrotic ectodermal dysplasia (HED) is a common recessive X-linked hereditary disease that affects the development of ectoderm. Gene mutations of ectodysplasin A (EDA) play key roles in process of this disease. In our preliminary study, three unknown mutation sites (c.878 T &...