A high‐throughput microfluidic mechanoporation platform to enable intracellular delivery of cyclic peptides in cell‐based assays

• Main Authors: Stephen H. Kasper (Author), Stephanie Otten (Author), Brian Squadroni (Author), Cionna Orr‐Terry (Author), Yi Kuang (Author), Lily Mussallem (Author), Lan Ge (Author), Lin Yan (Author), Srinivasaraghavan Kannan (Author), Chandra S. Verma (Author), Christopher J. Brown (Author), Charles W. Johannes (Author), David P. Lane (Author), Arun Chandramohan (Author), Anthony W. Partridge (Author), Lee R. Roberts (Author), Hubert Josien (Author), Alex G. Therien (Author), Erik C. Hett (Author), Bonnie J. Howell (Author), Andrea Peier (Author), Xi Ai (Author), Jason Cassaday (Author)
• Format: Book
• Published: Wiley, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Cyclic peptides are poised to target historically difficult to drug intracellular protein-protein interactions, however, their general cell impermeability poses a challenge for characterizing function. Recent advances in microfluidics have enabled permeabilization of the cytoplasmic membran...