Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets

• मुख्य लेखकों: Antonella Izzo (लेखक), Nunzia Mollo (लेखक), Maria Nitti (लेखक), Simona Paladino (लेखक), Gaetano Calì (लेखक), Rita Genesio (लेखक), Ferdinando Bonfiglio (लेखक), Rita Cicatiello (लेखक), Maria Barbato (लेखक), Viviana Sarnataro (लेखक), Anna Conti (लेखक), Lucio Nitsch (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2018-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is highly complex with constant features, such as mental retardation, dysmorphic traits and hypotonia, and variable features inclu...