Mitochondrial dysfunction in down syndrome: molecular mechanisms and therapeutic targets

• Main Authors: Antonella Izzo (Author), Nunzia Mollo (Author), Maria Nitti (Author), Simona Paladino (Author), Gaetano Calì (Author), Rita Genesio (Author), Ferdinando Bonfiglio (Author), Rita Cicatiello (Author), Maria Barbato (Author), Viviana Sarnataro (Author), Anna Conti (Author), Lucio Nitsch (Author)
• Format: Book
• Published: BMC, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is highly complex with constant features, such as mental retardation, dysmorphic traits and hypotonia, and variable features inclu...