Recombinant BCG vaccine expressing multistage antigens of Mycobacterium tuberculosis provides long-term immunity against tuberculosis in BALB/c mice

• Main Authors: Danang Fang (Author), Ruihuan Wang (Author), Xueting Fan (Author), Machao Li (Author), Chenyu Qian (Author), Bin Cao (Author), Jinjie Yu (Author), Haican Liu (Author), Yongliang Lou (Author), Kanglin Wan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTTuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) persistently kills nearly 1.5 million lives per year in the world, whereas the only licensed TB vaccine BCG exhibits unsatisfactory efficacy in adults. Taking BCG as a vehicle to express Mtb antigens is a promising way to enhance i...