Oligomer β-amyloid Induces Hyperactivation of Ras to Impede NMDA Receptor-Dependent Long-Term Potentiation in Hippocampal CA1 of Mice

• Những tác giả chính: Ya Wang (Tác giả), Zhaochun Shi (Tác giả), Yajie Zhang (Tác giả), Jun Yan (Tác giả), Wenfeng Yu (Tác giả), Ling Chen (Tác giả)
• Định dạng: Sách
• Được phát hành: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

The activity of Ras, a small GTPase protein, is increased in brains with Alzheimer's disease. The objective of this study was to determine the influence of oligomeric Aβ1-42 on the activation of Ras, and the involvement of the Ras hyperactivity in Aβ1-42-induced deficits in spatial cognition an...