Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors

Bruton tyrosine kinase (BTK) is linked to multiple signalling pathways that regulate cellular survival, activation, and proliferation. A covalent BTK inhibitor has shown favourable outcomes for treating B cell malignant leukaemia. However, covalent inhibitors require a high reactive warhead that may...

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Main Authors: Tony Eight Lin (Author), Li-Chin Sung (Author), Min-Wu Chao (Author), Min Li (Author), Jia-Huei Zheng (Author), Tzu-Ying Sung (Author), Jui-Hua Hsieh (Author), Chia-Ron Yang (Author), Hsueh-Yun Lee (Author), Er-Chieh Cho (Author), Kai-Cheng Hsu (Author)
Format: Book
Published: Taylor & Francis Group, 2022-01-01T00:00:00Z.
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