Thermodynamic Modeling of the Amorphous Solid Dispersion-Water Interfacial Layer and Its Impact on the Release Mechanism

• Main Authors: Stefanie Dohrn (Author), Samuel O. Kyeremateng (Author), Esther Bochmann (Author), Ekaterina Sobich (Author), Andrea Wahl (Author), Bernd Liepold (Author), Gabriele Sadowski (Author), Matthias Degenhardt (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During the dissolution of amorphous solid dispersion (ASD) formulations, the gel layer that forms at the ASD/water interface strongly dictates the release of the active pharmaceutical ingredient (API) and, hence, the dissolution performance. Several studies have demonstrated that the switch of the g...