Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice

• Main Authors: Nazmul Hasan (Author), Naoto Nagata (Author), Jun-ichi Morishige (Author), Md Tarikul Islam (Author), Zheng Jing (Author), Ken-ichi Harada (Author), Michihiro Mieda (Author), Masanori Ono (Author), Hiroshi Fujiwara (Author), Takiko Daikoku (Author), Tomoko Fujiwara (Author), Yoshiko Maida (Author), Tsuguhito Ota (Author), Shigeki Shimba (Author), Shuichi Kaneko (Author), Akio Fujimura (Author), Hitoshi Ando (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Impaired circadian clocks can cause obesity, but their pathophysiological role in brown adipose tissue (BAT), a major tissue regulating energy metabolism, remains unclear. To address this issue, we investigated the effects of complete disruption of the BAT clock on thermogenesis and energ...