Amide-to-Triazole Switch in Somatostatin-14-Based Radioligands: Impact on Receptor Affinity and In Vivo Stability

• Main Authors: Xabier Guarrochena (Author), Panagiotis Kanellopoulos (Author), Anna Stingeder (Author), Lisa-Maria Rečnik (Author), Irene V. J. Feiner (Author), Marie Brandt (Author), Wolfgang Kandioller (Author), Theodosia Maina (Author), Berthold A. Nock (Author), Thomas L. Mindt (Author)
• Format: Book
• Published: MDPI AG, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of metabolically stabilized, radiolabeled somatostatin (SST) analogs ([⁶⁸Ga]Ga/[¹⁷⁷Lu]Lu-DOTA-TATE/TOC/NOC) is well established in nuclear medicine. Despite the pivotal role of these radioligands in the diagnosis and therapy of neuroendocrine tum...