M2 Macrophages Promote PDGFRβ+ Pericytes Migration After Spinal Cord Injury in Mice via PDGFB/PDGFRβ Pathway

• Main Authors: Ziyu Li (Author), Meige Zheng (Author), Shuisheng Yu (Author), Fei Yao (Author), Yang Luo (Author), Yanchang Liu (Author), Dasheng Tian (Author), Li Cheng (Author), Juehua Jing (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Platelet derived growth factor receptor β positive (PDGFRβ+) pericytes form fibrotic scar, which prevents axonal regeneration after spinal cord injury (SCI). However, the mechanism by which PDGFRβ+ pericytes migrate to the injury core is unclear. Here, we investigated the effect and mechanism of mac...