Primary vaccination with low dose live dengue 1 virus generates a proinflammatory, multifunctional T cell response in humans.

• Main Authors: Janet C Lindow (Author), Nathan Borochoff-Porte (Author), Anna P Durbin (Author), Stephen S Whitehead (Author), Kelly A Fimlaid (Author), Janice Y Bunn (Author), Beth D Kirkpatrick (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The four dengue virus serotypes (DENV-1-DENV-4) have a large impact on global health, causing 50-100 million cases of dengue fever annually. Herein, we describe the first kinetic T cell response to a low-dose DENV-1 vaccination study (10 PFU) in humans. Using flow cytometry, we found that proinflamm...