Troglitazone Inhibits Vascular Endothelial Growth Factor-Induced Angiogenic Signaling via Suppression of Reactive Oxygen Species Production and Extracellular Signal-Regulated Kinase Phosphorylation in Endothelial Cells

• Main Authors: Byung Chul Park (Author), Dinesh Thapa (Author), Jong Suk Lee (Author), Su-Young Park (Author), Jung-Ae Kim (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thiazolidinediones, peroxisome proliferators-activated receptor gamma (PPARγ) ligands, have been recognized as a potential therapeutic agents for the treatment of pathological neovascularization. In the present study, we examined the molecular mechanism by which troglitazone (TROG), a PPARγ agonist,...