Gegen Qinlian standard decoction alleviated irinotecan-induced diarrhea via PI3K/AKT/NF-κB axis by network pharmacology prediction and experimental validation combination

• Main Authors: Jiamei Chen (Author), Min Li (Author), Rong Chen (Author), Ziyi Xu (Author), Xiaoqin Yang (Author), Huan Gu (Author), Lele Zhang (Author), Chaomei Fu (Author), Jinming Zhang (Author), Yihan Wu (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The frequently occurred chemotherapy-induced diarrhea (CID) caused by irinotecan (CPT-11) administration has been the most representative side-effects of CPT-11, resulting in the chemotherapy suspension or failure. Our previous studies indicated that Gegen Qinlian formula exhibit...