The role of skeletal muscle Akt in the regulation of muscle mass and glucose homeostasis

• Main Authors: N. Jaiswal (Author), M.G. Gavin (Author), W.J. Quinn, III (Author), T.S. Luongo (Author), R.G. Gelfer (Author), J.A. Baur (Author), P.M. Titchenell (Author)
• Format: Book
• Published: Elsevier, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Skeletal muscle insulin signaling is a major determinant of muscle growth and glucose homeostasis. Protein kinase B/Akt plays a prominent role in mediating many of the metabolic effects of insulin. Mice and humans harboring systemic loss-of-function mutations in Akt2, the most abundant Ak...