Involvement of Hypothalamic Glutamate in Cisplatin-Induced Emesis in Suncus murinus (House Musk Shrew)

• Main Authors: Kouichi Yamamoto (Author), Sze Wa Chan (Author), John A. Rudd (Author), Ge Lin (Author), Keiko Asano (Author), Atsushi Yamatodani (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated the effect of cisplatin on glutamate release in the hypothalamus of Suncus murinus measured by brain microdialysis. Dialysis samples were collected every 20 min for 1 h before and 3 h after the cisplatin (30 mg/kg, i.p.) administration with the animals also being observed for the dev...