VEGFR2-targeted antibody fused with IFNαmut regulates the tumor microenvironment of colorectal cancer and exhibits potent anti-tumor and anti-metastasis activity

• Main Authors: Pengzhao Shang (Author), Rui Gao (Author), Yijia Zhu (Author), Xiaorui Zhang (Author), Yang Wang (Author), Minji Guo (Author), Hui Peng (Author), Min Wang (Author), Juan Zhang (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although interferon α (IFNα) and anti-angiogenesis antibodies have shown appropriate clinical benefit in the treatment of malignant cancer, they are deficient in clinical applications. Previously, we described an anti-vascular endothelial growth factor receptor 2 (VEGFR2)-IFNα fusion protein named J...