De novo variant of TRRAP in a patient with very early onset psychosis in the context of non-verbal learning disability and obsessive-compulsive disorder: a case report

• Main Authors: Chrystal F. Mavros (Author), Catherine A. Brownstein (Author), Roshni Thyagrajan (Author), Casie A. Genetti (Author), Sahil Tembulkar (Author), Kelsey Graber (Author), Quinn Murphy (Author), Kristin Cabral (Author), Grace E. VanNoy (Author), Matthew Bainbridge (Author), Jiahai Shi (Author), Pankaj B. Agrawal (Author), Alan H. Beggs (Author), Eugene D'Angelo (Author), Joseph Gonzalez-Heydrich (Author)
• Format: Book
• Published: BMC, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background TRRAP encodes a multidomain protein kinase that works as a genetic cofactor to influence DNA methylation patterns, DNA damage repair, and chromatin remodeling. TRRAP protein is vital to early neural developmental processes, and variants in this gene have been associated with schi...