Selective Sparing of Striatal Interneurons after Poly (ADP-Ribose) Polymerase 1 Inhibition in the R6/2 Mouse Model of Huntington's Disease

• Asıl Yazarlar: Emanuela Paldino (Yazar), Antonella Cardinale (Yazar), Vincenza D'Angelo (Yazar), Ilaria Sauve (Yazar), Carmela Giampà (Yazar), Francesca R. Fusco (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2017-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Poly (ADP-ribose) polymerases (PARPs) are enzymes that catalyze ADP-ribose units transfer from NAD to their substrate proteins. It has been observed that PARP-1 is able to increase both post-ischemic and excitotoxic neuronal death. In fact, we have previously shown that, INO-1001, a PARP-1 inhibitor...