Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC-HRMS method

• Main Authors: Christelle Machon (Author), Frédéric Catez (Author), Nicole Dalla Venezia (Author), Floriane Vanhalle (Author), Laetitia Guyot (Author), Anne Vincent (Author), Maxime Garcia (Author), Béatrice Roy (Author), Jean-Jacques Diaz (Author), Jérôme Guitton (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

5-Fluorouracil (5-FU) is an anticancer drug extensively used for different cancers. Intracellular metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as enzymes, DNA and RNA. In this paper, we describ...