K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications

• Main Authors: Kengo Nakahata (Author), Brian W. Simons (Author), Enrico Pozzo (Author), Ryan Shuck (Author), Lyazat Kurenbekova (Author), Zachary Prudowsky (Author), Kshiti Dholakia (Author), Cristian Coarfa (Author), Tajhal D. Patel (Author), Lawrence A. Donehower (Author), Jason T. Yustein (Author)
• Format: Book
• Published: The Company of Biologists, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, with overall long-term survival rates of ∼65-70%. Thus, additional molecular insights and representative models are critical for identifying and evaluating new treatment modalities. Using MyoD-Cre-mediated introduction of mut...