VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

• Main Authors: Ning Ji (Author), Yuqi Yang (Author), Chao-Yun Cai (Author), Zi-Ning Lei (Author), Jing-Quan Wang (Author), Pranav Gupta (Author), Qiu-Xu Teng (Author), Zhe-Sheng Chen (Author), Dexin Kong (Author), Dong-Hua Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for multi-drug resistance (MDR). VS-4718, a tyrosine kinase inhibitor targeting focal adhesion kinase (FAK) with a potential anticancer effect, is currently evaluated in clinical trials. In...