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VS-4718 Antagonizes Multidrug Resistance in ABCB1- and ABCG2-Overexpressing Cancer Cells by Inhibiting the Efflux Function of ABC Transporters

Overexpression of ATP-binding cassette (ABC) transporters is one of the most important mechanisms responsible for multi-drug resistance (MDR). VS-4718, a tyrosine kinase inhibitor targeting focal adhesion kinase (FAK) with a potential anticancer effect, is currently evaluated in clinical trials. In...

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Main Authors:	Ning Ji (Author), Yuqi Yang (Author), Chao-Yun Cai (Author), Zi-Ning Lei (Author), Jing-Quan Wang (Author), Pranav Gupta (Author), Qiu-Xu Teng (Author), Zhe-Sheng Chen (Author), Dexin Kong (Author), Dong-Hua Yang (Author)
Format:	Book
Published:	Frontiers Media S.A., 2018-10-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
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