Population Pharmacokinetics and Pharmacodynamic Target Attainment of Isavuconazole against <i>Aspergillus fumigatus</i> and <i>Aspergillus flavus</i> in Adult Patients with Invasive Fungal Diseases: Should Therapeutic Drug Monitoring for Isavuconazole Be Considered as Mandatory as for the Other Mold-Active Azoles?

• Main Authors: Pier Giorgio Cojutti (Author), Alessia Carnelutti (Author), Davide Lazzarotto (Author), Emanuela Sozio (Author), Anna Candoni (Author), Renato Fanin (Author), Carlo Tascini (Author), Federico Pea (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Isavuconazole is a newer broad-spectrum triazole approved for the treatment of invasive fungal disease. The objective of this study was to conduct a population pharmacokinetic and pharmacodynamic analysis of isavuconazole in a retrospective cohort of hospitalized patients. A nonlinear mixed-effect a...