Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction

• Main Authors: Devika P. Bagchi (Author), Ziru Li (Author), Callie A. Corsa (Author), Julie Hardij (Author), Hiroyuki Mori (Author), Brian S. Learman (Author), Kenneth T. Lewis (Author), Rebecca L. Schill (Author), Steven M. Romanelli (Author), Ormond A. MacDougald (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Obesity is a key risk factor for many secondary chronic illnesses, including type 2 diabetes and cardiovascular disease. Canonical Wnt/β-catenin signaling is established as an important endogenous inhibitor of adipogenesis. This pathway is operative in mature adipocytes; however, its role...