High initial IgG antibody levels against Orientia tsutsugamushi are associated with an increased risk of severe scrub typhus infection.

• Main Authors: Carol S Devamani (Author), John A J Prakash (Author), Neal Alexander (Author), William Stone (Author), Karthik Gunasekaran (Author), Winsley Rose (Author), Wolf-Peter Schmidt (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Scrub typhus is a dominant cause of febrile illness in many parts of Asia. Immunity is limited by the great strain diversity of Orientia tsutsugamushi. It is unclear whether previous infection protects from severe infection or enhances the risk.<h4>Methods/princi...