Pyridinium-2-carbaldoximes with quinolinium carboxamide moiety are simultaneous reactivators of acetylcholinesterase and butyrylcholinesterase inhibited by nerve agent surrogates

• Main Authors: Hyun Myung Lee (Author), Rudolf Andrys (Author), Jakub Jonczyk (Author), Kyuneun Kim (Author), Avinash G. Vishakantegowda (Author), David Malinak (Author), Adam Skarka (Author), Monika Schmidt (Author), Michaela Vaskova (Author), Kamil Latka (Author), Marek Bajda (Author), Young-Sik Jung (Author), Barbara Malawska (Author), Kamil Musilek (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pyridinium-2-carbaldoximes with quinolinium carboxamide moiety were designed and synthesised as cholinesterase reactivators. The prepared compounds showed intermediate-to-high inhibition of both cholinesterases when compared to standard oximes. Their reactivation ability was evaluated in vitro o...