S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis

• Үндсэн зохиолчид: Fei Liu (Зохиогч), Longhui Yuan (Зохиогч), Lan Li (Зохиогч), Jingchao Yang (Зохиогч), Jingping Liu (Зохиогч), Younan Chen (Зохиогч), Jie Zhang (Зохиогч), Yanrong Lu (Зохиогч), Yujia Yuan (Зохиогч), Jingqiu Cheng (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Elsevier, 2023-06-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Senescence of bone marrow mesenchymal stem cells (BMSCs) is one of the leading causes of osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, is highly correlated with BMSC senescence-mediated bone degradation and mitochondrial/heterochromatic disturbance. S-sulfhydration of cysteine...