S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis

• Main Authors: Fei Liu (Author), Longhui Yuan (Author), Lan Li (Author), Jingchao Yang (Author), Jingping Liu (Author), Younan Chen (Author), Jie Zhang (Author), Yanrong Lu (Author), Yujia Yuan (Author), Jingqiu Cheng (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Senescence of bone marrow mesenchymal stem cells (BMSCs) is one of the leading causes of osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, is highly correlated with BMSC senescence-mediated bone degradation and mitochondrial/heterochromatic disturbance. S-sulfhydration of cysteine...