Immortalizing Mesenchymal Stromal Cells from Aged Donors While Keeping Their Essential Features

• Main Authors: María Piñeiro-Ramil (Author), Rocío Castro-Viñuelas (Author), Clara Sanjurjo-Rodríguez (Author), Silvia Rodríguez-Fernández (Author), Tamara Hermida-Gómez (Author), Francisco J. Blanco-García (Author), Isaac Fuentes-Boquete (Author), Silvia Díaz-Prado (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human bone marrow-derived mesenchymal stromal cells (MSCs) obtained from aged patients are prone to senesce and diminish their differentiation potential, therefore limiting their usefulness for osteochondral regenerative medicine approaches or to study age-related diseases, such as osteoarthiritis (...