Quercetin's Dual Mode of Action to Counteract the Sp1-miR-27a Axis in Colorectal Cancer Cells

• Main Authors: Emanuele Fosso (Author), Manuela Leo (Author), Livio Muccillo (Author), Vittorio Maria Mandrone (Author), Maria Chiara Di Meo (Author), Annamaria Molinario (Author), Ettore Varricchio (Author), Lina Sabatino (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Quercetin (Qc) inhibits cell proliferation and induces apoptosis in a variety of cancer cells. The molecular mechanism of action has not been fully elucidated; however, interplay with some miRNAs has been reported, specifically with miR-27a, an onco-miRNA overexpressed in several malignancies. Here,...