Characterization of cooperative PS-oligo activation of human TLR9

Single-stranded phosphorothioate oligonucleotides (PS-oligos) can activate TLR9, leading to an innate immune response. This can occur with PS-oligos containing unmethylated CpG sites, the canonical motif, or PS-oligos that do not contain those motifs (non-CpG). Structural evidence shows that TLR9 co...

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Main Authors: Adam J. Pollak (Author), Luyi Zhao (Author), Stanley T. Crooke (Author)
Format: Book
Published: Elsevier, 2023-09-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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