Effects of Methotrexate on Plasma Cytokines and Cardiac Remodeling and Function in Postmyocarditis Rats

• Main Authors: Zhengang Zhang (Author), Pei Zhao (Author), Aihua Li (Author), Xiaolei Lv (Author), Yang Gao (Author), Hongguang Sun (Author), Yongling Ding (Author), Jian Liu (Author)
• Format: Book
• Published: Hindawi Limited, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excessive immune activation and inflammatory mediators may play a critical role in the pathogenesis of chronic heart failure. Methotrexate is a commonly used anti-inflammatory and immunosuppressive drug. In this study, we used a rat model of cardiac myosin-induced experimental autoimmune myocarditis...