Quality by Design-driven investigation of the mechanical properties of mucoadhesive films for needleless anesthetics administration

• Auteurs principaux: Luiz Fernando Machado Ferreira (Auteur), Douglas Vieira Thomaz (Auteur), Maíra Peres Ferreira Duarte (Auteur), Renata Fonseca Vianna Lopez (Auteur), Vinícius Pedrazzi (Auteur), Osvaldo de Freitas (Auteur), Renê Couto (Auteur)
• Format: Livre
• Publié: São Paulo State University (UNESP), 2021-03-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Objectives: To systematically evaluate the effects of hydroxypropyl methyl cellulose (HPMC) type (E5LV, E15LV, and K100LV); plasticizer type (glycerol and mannitol), plasticizer loading (0.12 and 0.24% w/w); and loading of prilocaine and lidocaine hydrochlorides combined at 1:1 ratio (0 and 47 mg/cm...