Quality by Design-driven investigation of the mechanical properties of mucoadhesive films for needleless anesthetics administration

• Main Authors: Luiz Fernando Machado Ferreira (Author), Douglas Vieira Thomaz (Author), Maíra Peres Ferreira Duarte (Author), Renata Fonseca Vianna Lopez (Author), Vinícius Pedrazzi (Author), Osvaldo de Freitas (Author), Renê Couto (Author)
• Format: Book
• Published: São Paulo State University (UNESP), 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: To systematically evaluate the effects of hydroxypropyl methyl cellulose (HPMC) type (E5LV, E15LV, and K100LV); plasticizer type (glycerol and mannitol), plasticizer loading (0.12 and 0.24% w/w); and loading of prilocaine and lidocaine hydrochlorides combined at 1:1 ratio (0 and 47 mg/cm...