Individual islet respirometry reveals functional diversity within the islet population of mice and human donors

• Main Authors: Evan P. Taddeo (Author), Linsey Stiles (Author), Samuel Sereda (Author), Eleni Ritou (Author), Dane M. Wolf (Author), Muhamad Abdullah (Author), Zachary Swanson (Author), Josh Wilhelm (Author), Melena Bellin (Author), Patrick McDonald (Author), Kacey Caradonna (Author), Andrew Neilson (Author), Marc Liesa (Author), Orian S. Shirihai (Author)
• Format: Book
• Published: Elsevier, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Islets from the same pancreas show remarkable variability in glucose sensitivity. While mitochondrial respiration is essential for glucose-stimulated insulin secretion, little is known regarding heterogeneity in mitochondrial function at the individual islet level. This is due in part to...