Histone deacetylase inhibition reduces cardiac Connexin43 expression and gap junction communication

• Main Authors: Qin eXu (Author), Xianming eLin (Author), Laura eAndrews (Author), Dakshesh ePatel (Author), Paul D Lampe (Author), Richard David Veenstra (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Histone deactylase (HDAC) inhibitors are being investigated as novel therapies for cancer, inflammation, neurodegeneration, and heart failure. The effects of HDAC inhibitors on the functional expression of cardiac gap junctions (GJ) are essentially unknown. The purpose of this study was to determine...