LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

• Autors principals: Gao Sun (Autor), Gabriela da Silva Xavier (Autor), Tracy Gorman (Autor), Claire Priest (Autor), Antonia Solomou (Autor), David J. Hodson (Autor), Marc Foretz (Autor), Benoit Viollet (Autor), Pedro-Luis Herrera (Autor), Helen Parker (Autor), Frank Reimann (Autor), Fiona M. Gribble (Autor), Stephanie Migrenne (Autor), Christophe Magnan (Autor), Anna Marley (Autor), Guy A. Rutter (Autor)
• Format: Llibre
• Publicat: Elsevier, 2015-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Aims/Hypothesis: Glucagon release from pancreatic alpha cells is required for normal glucose homoeostasis and is dysregulated in both Type 1 and Type 2 diabetes. The tumour suppressor LKB1 (STK11) and the downstream kinase AMP-activated protein kinase (AMPK), modulate cellular metabolism and growth,...