LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

• Main Authors: Gao Sun (Author), Gabriela da Silva Xavier (Author), Tracy Gorman (Author), Claire Priest (Author), Antonia Solomou (Author), David J. Hodson (Author), Marc Foretz (Author), Benoit Viollet (Author), Pedro-Luis Herrera (Author), Helen Parker (Author), Frank Reimann (Author), Fiona M. Gribble (Author), Stephanie Migrenne (Author), Christophe Magnan (Author), Anna Marley (Author), Guy A. Rutter (Author)
• Format: Book
• Published: Elsevier, 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims/Hypothesis: Glucagon release from pancreatic alpha cells is required for normal glucose homoeostasis and is dysregulated in both Type 1 and Type 2 diabetes. The tumour suppressor LKB1 (STK11) and the downstream kinase AMP-activated protein kinase (AMPK), modulate cellular metabolism and growth,...