Intravital imaging of a massive lymphocyte response in the cortical dura of mice after peripheral infection by trypanosomes.

• Main Authors: Jonathan A Coles (Author), Elmarie Myburgh (Author), Ryan Ritchie (Author), Alana Hamilton (Author), Jean Rodgers (Author), Jeremy C Mottram (Author), Michael P Barrett (Author), James M Brewer (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peripheral infection by Trypanosoma brucei, the protozoan responsible for sleeping sickness, activates lymphocytes, and, at later stages, causes meningoencephalitis. We have videoed the cortical meninges and superficial parenchyma of C56BL/6 reporter mice infected with T.b.brucei. By use of a two-ph...