Comparison of Various Cell Lines and Three-Dimensional Mucociliary Tissue Model Systems to Estimate Drug Permeability Using an In Vitro Transport Study to Predict Nasal Drug Absorption in Rats

• Hauptverfasser: Tomoyuki Furubayashi (Verfasst von), Daisuke Inoue (Verfasst von), Noriko Nishiyama (Verfasst von), Akiko Tanaka (Verfasst von), Reiko Yutani (Verfasst von), Shunsuke Kimura (Verfasst von), Hidemasa Katsumi (Verfasst von), Akira Yamamoto (Verfasst von), Toshiyasu Sakane (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2020-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Recently, various types of cultured cells have been used to research the mechanisms of transport and metabolism of drugs. Although many studies using cultured cell systems have been published, a comparison of different cultured cell systems has never been reported. In this study, Caco-2, Calu-3, Mad...